15018752330
发表时间:2015-12-08 浏览次数:485次
Radiesse (Merz Aesthetics, Franksville, WI, USA) is an injectable filler
material composed of synthetic calcium hydroxylapatite (CaHA)
microspheres suspended in an aqueous carrier gel. Cosmetic use of
Radiesse in facial rejuvenation is well-known. Treatment sites amenable
to calcium hydroxylapatite (CH) injection include the naso-labial folds,
marionette lines, perioral lines, prejowl sulcus, zygoma and malar
eminence, tear trough depressions, nose, chin, acne scars, and it is
also Food and Drug Administration-approved for facial augmentation in
HIV patients with facial lipo-atrophy. [1]
Calcium hydroxylapatite filler enjoy an excellent safety record. The
adverse events reported are similar to those observed with other
short-acting fillers such as hyaluronic acid. There is no evidence of
granuloma formation occurring with CaHA. [1]
Although, presence of visible skin nodules has been reported, they are
related to techniques, especially due to superficial injection of CH or
its inappropriate use.
We describe a unique unreported
complication, related to CH filler injection in an HIV positive patient.
A 37-year-old, HIV positive, Caucasian male patient was referred to our
University Hospital for facial lipo-atrophy rehabilitation [Figure 1]. We performed, as per our protocol, [2] the rehabilitation in one session injecting 7.5 mL of CH filler. After 10 days postinjection swelling and hematoma resolved [Figure 2].
Three weeks later, the patient came back to us with a complaint of a
soft tissue swelling, involving the areas where the filler was injected [Figure 3].
The swelling was soft, nontender with sudden onset in the morning after
waking up from sleep. A bromelina based therapy was prescribed for a
week (Ananase, Rottapharm S.p.a., Milano) by us. After 2 weeks the
swelling resolved completely with no recurrence in 8 months of follow-up [Figure 4].
To the best of our knowledge and after extensive literature search we
could not determine the reason for this complication nor has such
adverse effect ever reported in the literature.
References
1.Graivier MH, Bass LS, Busso M, Jasin ME, Narins RS, Tzikas TL. Calcium hydroxylapatite (Radiesse) for correction of the mid- and lower face: consensus recommendations. Plast Reconstr Surg 2007;120:55S-66S.
2.Rauso R, Curinga G, Rusciani A, Colella G, Amore R, Tartaro G. Safety and efficacy of one-step rehabilitation of human immunodeficiency virus-related facial lipoatrophy using an injectable calcium hydroxylapatite dermal filler. Dermatol Surg 2013;39:1887-94.