血清胱抑素C和尿微量蛋白联合检测在糖尿病肾病早期诊断中的价值

[1] 刘贞.血清胱抑素C和尿微量蛋白联合检测在糖尿病肾病早期诊断中的价值[J].吉林医学,2013,34(33):6889-6890.

胱抑素C；微量蛋白；糖尿病肾病

刘贞

江苏省沛县人民医院检验科,江苏沛县,221600

2014年

6889-6890

万方

目的:探讨血清胱抑素C (Cys-c),尿微量白蛋白(mAlb)、尿β2-微球蛋白(β2、-m)与尿α1-微球蛋白(α1-m)联合测定在糖尿病肾病(DN)早期诊断中的价值.方法:对82例健康体检者(对照组)及150例在不同病程2型糖尿病(DM)患者进行血清胱抑素C(Cys-c)、尿(mAlb、β2-m、α1-m)含量的测定并进行相关性分析.结果:与对照组相比,A组(DM病程＜10年)和B组(DM病程10年以上)各项检测指标均明显增高,差异有统计学意义(P＜0.05).而A组各指标则低于B组,差异有统计学意义(P＜0.05).结论:血清胱抑素C与尿微量白蛋白、β2-微球蛋白、α1-微球蛋白的联合测定可作为DN的早期诊断指标. Abstract:Objective To investigate the relationship between serum cystatin C(Cys-c),urinary albumin(mAlb),urinary β2 -microglobulin(β2 ,-m) and urinary α1 -microglobulin (α1 -m) and in patients with diabetic nephropathy(DN) in the early diagnosis of value. Methods 82 healthy subjects(control group) and 150 cases in different courses of type 2 diabetes(DM) patients serum cystatin C(Cysc),urine(mAlb,β2 -m,α1 -m) and determination of the correlation analysis.Results Compared with control group,A group(DM＜10 years duration) and group B (DM more than 10 years duration) detect each index all increased obviously,the difference was statistically significant(P＜0.05).And every index of A group is lower than that in B group,the difference was statistically significant(P＜0.05).Conclusion The serum cystatin C and urinary albumin,beta 2-microglobulin,alpha 1-microglobulin determination can be used as an early diagnostic marker for DN.。