miR-15家族在肝脏疾病中的作用

马丽霞，韦新焕，张晶.miR-15家族在肝脏疾病中的作用[J].临床肝胆病杂志, 2013, 29(2).158-161

微RNAs 肝炎,慢性 肝硬化 肝功能衰竭,急性 癌,肝细胞

马丽霞，韦新焕，张晶

首都医科大学附属北京佑安医院人工肝中心,北京,100069

2013年

158-161

知网,万方

微小RNA(miRNA)是一类最新发现的短小内源性非编码RNA,其中miR-15家族生理状态下参与细胞凋亡、分化与周期调控、应激等重要细胞功能活动的调节,而在病理状态下与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关,具有潜在的治疗前景.本文就miR-15家族在肝癌、急性肝衰竭、肝纤维化和慢性肝病中的重要功能及治疗应用前景作一综述. Abstract:Since their recent discovery，microR}TAs(miRV As )，a class of short endogenous non一coding RNAs，have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes. Under normal physiological conditions，the miR一15 family members regulate several important cellular functions，including apoptosis，cell differentiation, cell cycle, and stress re- sponses. However, under pathological conditions，the miR一15 family members contribute to carcinogenesis，cardiovascular dysfunctions， and neurodegeneration; these activities may represent potentially useful targets of molecular therapeutic strategies. In this review, we summa- rize and discuss the important functions and promising therapeutic applications of the miR一15 family in liver cancer, acute liver failure，liv- er fibrosis，and liver damage.。