雷贝拉唑治疗幽门螺杆菌阴性胃溃疡的临床研究

吴秀华,聂正全.雷贝拉唑治疗幽门螺杆菌阴性胃溃疡的临床研究[J].吉林医学,2013,34(28):5793-5795.

胃溃疡 知识脉络 Hp阴性 知识脉络 雷贝拉唑 知识脉络 奥美拉唑 知识脉络

吴秀华 聂正全

四川省天全县中医院,四川,天全,625500

2013年

5793-5795

知网,万方

目的:观察雷贝拉唑治疗幽门螺杆菌(Hp)阴性胃溃疡的临床疗效与安全性.方法:收集经胃镜检查证实患Hp阴性胃溃疡的患者并随机分成治疗组与对照组,治疗组50例,对照组50例,治疗组服用雷贝拉唑肠溶胶囊1粒(20 mg/粒),2次/d,对照组服用奥美拉唑肠溶胶囊1粒(20 mg/粒),2次/d,疗程6周.结果:胃溃疡的治愈率两组分别为93.70%与94%,差异无统计学意义(P＞0.05).治疗期间患者对两组药物均有较好的耐受性.结论:雷贝拉唑治疗Hp阴性胃溃疡有较高的治愈率与症状改善率,疗效与奥美拉唑相当,是一种安全、有效的新一代质子泵抑制剂. ObjectiveTo observe the effect and safety of applying Rabeprazole in treatment of active gastric ulcer without Hp infection.Method100 patients with gastric ulcer without Hp infection were divided randomly into trail group and control group，50 patients in trail group received Rabeprazole 40 mg qd for 6 weeks，while 50 patients in control group received Omeprazole 40 mg qd for 6 weeks.ResultsAfter 6 weeks′ treatment， gastric ulcer withfout Hp infection healing rates were 94% in the Rabeprazole group and 92% in the Omeprazole group， there was no significant statistical difference between the Rabeprazole group and the Omeprazole group(P＞0.05),and both drugs were well tolerated.ConclusionIn this study， healing rate of Rabeprazole is equal to Omeprazole in gastric ulcer without Hp infection，Rabeprazole is an efffective and safe drug for the treatment of active gastric ulcer without Hp infection.。