溃疡性结肠炎的发病特点与“毒损肠络”病机学说

王新月，闫昕.溃疡性结肠炎的发病特点与“毒损肠络”病机学说[J]. 中国中西医结合杂志.2013.33.(3):410-414.

溃疡性结肠炎;毒损肠络;病机;微血管炎

王新月，闫昕

北京中医药大学东直门医院消化科

2013年

410-414

知网

溃疡性结肠炎(ulcerative colitis,UC)是病因不明的一种慢性非特异性肠道炎症,治愈难度大,常反复发作,甚至伴有肠外病变,被世界卫生组织列为现代难治病之一。笔者将中医毒邪学说、络病学说与UC发病机制相结合,提出"毒损肠络"病机学说,认为湿热瘀毒积久损伤肠络是UC反复发作、缠绵难愈的病机关键,从中医及现代医学发病机制角度阐释其理论基础,完善UC辨证论治体系,为临床治疗该病提供新思路。 Ulcerative colitis(uc)，a kind of chronic nonspecific intestinal inflammation with un- known etiology，is very difficult to cure. It recurs often and even is accompanied with parenteral lesion. It has been rated as one of contemporary refractory diseases by World Health Organization. The author combines the pathological mechanisms of UC with the poison-evil theory and the collateral disease theo- ry，and puts forward that“toxin impairing intestine collateral”pathogenesis theory·We believe that longer accumulation of damp-heat stasis toxin that damages the intestine collateral is the key cause for recur- rence and relapses of UC. We explained its theory foundation in terms of pathogenesis of UC from Chi- nese medicine and modern medicine. The“toxin impairing intestine collateral”theory might perfect the syndrome typing system for UC，and provide a new way of thinking for treating UC.。