支气管哮喘气道重塑的研究进展

栾一鸣,宋小莲,王昌惠等.支气管哮喘气道重塑的研究进展[J].国际呼吸杂志,2013,33(5):362-365.

支气管哮喘;气道重塑,气道平滑肌

栾一鸣 宋小莲 王昌惠

同济大学附属第十人民医院呼吸内科,上海,200072

2014年

362-365

万方

支气管哮喘(简称哮喘)是气道慢性炎症和组织改变共同参与的疾病.慢性炎症反应与气道重塑密切相关,炎症细胞和组织细胞释放多种细胞因子、趋化因子和生长因子,在气道组织里形成了复杂的信号环境促成了气道重塑.气道重塑包括一系列病理生理学特征.本文结合近年来哮喘气道重塑的文献,就病理学特点和最新机制性研究作一综述. Bronchial asthma (asthma) is a lung disease invloved by both airway chronic inflammatory and structural alterations.Remodeling is associated with airway chronic inflammatory response.Multiple cytokines,chemokines,and growth factors released from both inflammatory and structural cells in the airway tissue form a complex signaling environment that facilitate these structural changes,which contain a wide array of pathophysiologic features.In this paper,we will make a review on pathology feathers and latest mechanism researches based on recent literatures on airway remodeling in asthma.。